Roche Laboratories, Switzerland, 1976
The influence of Seatone (RO 49-0282/100), and fractions of Seatone, on the established adjuvant arthritis of the rat.
This study demonstrated that GLME had anti-inflammatory activity in a rat model of arthritis. The study also tested isolated fractions of GLME for anti-inflammatory activity, but each of these fractions alone had no effect. This supports the argument that it is the combination of elements in GLME (rather than a single compound) that confers its anti-inflammatory activity.