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学術論文

Townsend Letter for Doctors & Patients 2000; 204:99-111

New Research and a Clinical Report on the Use of Perna Canaliculus in the Management of Arthritis

Kendall RV, Lawson JW, Hurley LA.

緑イ貝エキス末に関する論文の完全なレビューであり、その抗炎症活性や関節炎患者における臨床的な利益について述べています。特に、この報告は緑イ貝エキス末にグルコサミノグリカン類(関節の軟骨や滑液の重要な成分)、さらにグリコーゲンや特定の不飽和多価脂肪酸、リゾレシチンなどの抗炎症成分がどのように含有されるかを中心に記述されています。また筆者は、関節炎誘導動物モデルにおける抗炎症活性や慢性関節炎患者における症状改善と可動性改善を示した臨床試験を再評価しています。

Abstract

Perna canaliculus (Perna) is a species of green-lipped mussel found off the waters of New Zealand. For centuries this edible shellfish has been a major part of the diet of the local populations. In 1974 it was found to be a potential natural remedy for arthritis. Numerous animal and human studies, published between 1975 and 1993, have indicated that this product from the sea might offer safe and effective relief from the pain, inflammation, and other debilitating symptoms associated with both rheumatoid and osteoarthritis. Earlier animal studies focused primarily on the anti-inflammatory properties of Perna mussel and its ability to prevent the onset of induced arthritis. Several human studies gave positive results as to the mussel’s ability to relieve multiple symptoms of arthritis when compared to conventional anti-inflammatory drugs. The beneficial properties of Perna have been linked to the presence of complex polysaccharides known as glycosaminoglycans (GAGs) but studies have also shown that other components in Perna mussel may also contribute to its therapeutic effects. Recent findings at Clemson University confirmed the earlier anti-inflammatory properties of Perna in both rat and mouse arthritic models. Perna mussel also exerts a strong immune modulating effect which may explain its mechanism of action. A recently completed clinical evaluation on over one hundred patients suffering from osteoarthritis of the knee demonstrates Perna’s potential in providing effective management of arthritis. Perna canaliculus has been shown to relieve arthritic symptoms and may halt the progression of the condition as well as provide nutritional support for the actual regeneration of connective tissue in the affected joints.