Shark have swum in the sea for the last 400 million years. Although the dinosaurs died out,
sharks still remain and are probably the longest living animal on earth. The shark's individual
life span is 25-100 years, though some have lived for longer.
So why have sharks out-lived the dinosaurs?
The strong and effective immunity function of the shark is a source of its longevity.
When sharks are injured, healing takes place very quickly and infection hardly ever occurs.
An antibody in their blood deals with bacteria, viruses, and protect sharks from chemical
substances which most animals would die from. A pioneer of hsark immunity function
research- Mr Sheigel, found the peculiarity that globulin always circulates in shark's
blood in preparation for any bacterial attack(Miami Univ. 1960).
Sharks are likely to live a long life because they are not likely to get cancer.
In fact the occurrence rate of cancer in sharks is less than 1% of that in normal fish.
Even sharks kept in water containing carcinogens did not develop the disease. Why- because
they have rich reserves of a repressive substance that fights off cancer.
Everybody has cancer genes that can cause cancer. Our body is made from about 60 trillion cells,
one of them being a cancer cell. A cell has a nucleus and a membrane. There are cancer genes
in each nucleus. Cancer cells can multiply without limit(autonomous propagation), moving into
internal organs close by (permeation), or leaping to distant internal organs(metastasis).
The birth of cancer cells starts when inactive cancer genes in a normal condition wake up.
The substance that awakens cancer genes is the initiator of carcinogenesis.
The Awakening of Cancer genes and completion of cancer cells
A carcinogenic substance initiates a variation in cellular genes and the cell starts to
become cancerous. Complete cancer cells cannot be restored to normal, so for growth to occur,
cell dividison takes place. Cancer cells created by cell division cannot be returned to their
normal state. These cells are called "cells at the beginning of a cancerous change".
A carcinogenic catalyst acts on these cells and cancer cells are completed.
Marine Derived Lipid comes from the flesh of certain species of shark and is an oil containing a
unique ratio of omega-3 fatty acids. Unlike a number of other anti-angiogenic products,
it doesn't need injecting and it seems to have few toxic side effects.
The Differences of Marine Derived Lipid
Scientists around the world have been testing dozens of different anti-angiogenesis materials
such as the notorious drug thalidomide and alpha-interferon. Marine Derived Lipid can be taken orally
as a pill. A number of other anti-angiogenic materials need to be injected because they are
protein based and they break down quickly in the digestive system. But Marine Derived Lipid doesn't.
Anti-angiogenesis
Except in a few special circumstances, angiogenesis does not occur in the normal adult.
The growth of blood vessels is most active in children. So, when you do have angiogenesis
occurring in an adult, it is frequently in a disease type situation, such as tumors,
diabetic retinopathy-where people go blind, macular degeneration, and arthritis. The concept
of anti-angiogenesis is not new and is based on the deceptively simple idea that tumors might
be defeated - starved to death - if their blood supply can be blocked.
To grow and ultimately, metastasise, malignant tumors must attract a rich blood supply to
obtain nourishment and remove wastes.
Marine Derived Lipid has been shown to have potent anti-angiogenic activity. It inhibits
the effects of Vascular Endothelial Growth Factor (VEGF), Basic Fibroblast Growth Factor
(FGF-2) and Transforming Growth Factor-β (TGF-β), known as angiogenesis factors. Especially
VEGF has an intimate involvement in angiogenesis for growth of solid carcinoma.
According to latest studies, it has been shown that Marine Derived Lipid can bind
to both the R1 and R2 receptors for VEGF and thereby prevent VEGF binding to the cell surface.
VRGF is one of the most potent stimulators of angiogenesis, therefore preventing VEGF binding
to the cell surface can stop the signal to grow neovascularities.
Percentage inhibition of angiogenesis
Percentage inhibition of angiogenesis in rat aorta strip (in vitro)
| Sample | Angiogenesis Inhibition |
| 1mg/ml | 0.1mg/ml | 0.04mg/ml | 0.01mg/ml |
| Marine Derived Lipid | - | 100% | 90% | 73% |
| Shark Cartilage | 73% | - | - | - |
| Shark Liver Oil | - | 24% | - | - |
| Codfish Liver Oil | - | 42% | - | - |
用大鼠的腸間膜作血管新生抑制率的體內實驗(in vivo)
| 未使用鯊魚脂質 |
鯊魚脂質 12mg/kg |
 |
 |
如圖所示，未使用鯊魚脂質的動物腹腔内有許多新生血管，與此相比較，使用鯊魚脂質的動物腹腔内的新生血管被抑制。
Marine Derived Lipid is also an effective cure for Brain Tumor.
Ginza San Espero Omori Clinic, Dr. Takashi Omori
Marine Derived Lipid was studied and developed by Otago University and Industrial Research
Ltd in New Zealand. It is a lipid which controls abnormal angiogenesis, occurring especially
in cases of cancer, and is extracted from oils which constitute shark cell membranes etc.
According to the experiments carried by Medical Department of Otago University, it was found
that the Marine Derived Lipid effectively prevents angiogenesis and controls its growth.
It has 100 times in vitro and 30 times in vivo as much anti-angiogenesis ability as shark
cartilage powder. It is a substance which is the centre of attention in recent years.
According to Dr.Omori who has tried the Marine Derived Lipid in an early stage,
another effect on cerebral neoplasm has been expected.
Domestic research institutes in Japan are currently conducting the clinical studies.
The concrete fact is as follow; After being prescribed 15 capsules of Marine Derived Lipid
per day for a cerebral neoplasm patient who also developed metastasis lung cancer, a tumor in
his brain tended to shrink. Additionally, the fact that the size of 3-4cm lung tumor has become
smaller was observed.
Regarding this point, Dr. Omori analyzes as follow: When a tumor develops into a brain,
the tumor has to pass through a blood brain barrier on a blood vessel wall. This is because
such barrier system in a brain blood vessel allows only certain substances, such as glucan
and insulin to get into.
It is possible for Marine Derived Lipid to go through the blood vessel wall, because of its
nature, which allows liquid to go through it. This is possibly because the main substance of
Marine Derived Lipid and substances which are contained in blood vessel wall cells share common
substances such as EPA and DHA. Therefore, this may be shown to increase the permeability of
blood vessel walls.
Dr. Omori says that the use of both shark cartridge powder and Marine Derived Lipid,
which attacks from outside and inside of the cells respectively, on his patients can be taken
into account in the future.